the binding of isaac antibirth mines knife piece

Ascent/ Home (Repentance DLC): Defeat Mother in Corpse once.

To access Corpse, open the door at the end of the Mausoleum II/Gehenna II it is opened using Knife Pieces 1 and 2 that you collect from Downpour and the Mines respectively.

Corpse (Repentance DLC): Defeat Hush 3 times.

Gehenna (Repentance DLC): Defeat all bosses in the Mausoleum, appears as an alternate chapter to the Mausoleum.

To access the Mausoleum, open the door that appear in The Depths I, its alternates, or the Mines II that takes 2 hearts to enter (except when playing The Lost).

Mausoleum (Repentance DLC): Defeat Hush 3 times.

Ashpit (Repentance DLC): Defeat all bosses in the Mines, appears as an alternate chapter to the Mines.

To access the Mines, bomb the wall in the last room of The Caves I/II or its alternates.

Mines (Repentance DLC): Defeat Hush 3 times.

Dross (Repentance DLC): Defeat all bosses in Downpour, appears as an alternate chapter to Downpour.

To access Downpour, open the locked door at the end of The Basement or its alternates.

Downpour (Repentance DLC): Defeat Hush 3 times.

50% chance after Mega Satan (Chest/Dark Room).

20% chance after ? (Chest) or The Lamb (Dark Room).

15% chance after Isaac (Cathedral) or Satan (Sheol).

5% chance after Mom (and only if you have a lot of damage or items).

Once you've reached The Void for the first time, there is a chance of a Portal to The Void appearing after these bosses:

The Void (Afterbirth+ DLC): Kill Hush in The Blue Womb.

Blue Womb (Afterbirth DLC): Kill It Lives in 30 minutes or less.

Collecting both key pieces or using Dad's Key will unlock the giant door in The Chest or The Dark Room, allowing you to fight Mega Satan.

Getting both key pieces in the same run will unlock Dad's Key.The Key Pieces are gotten by going to an Angel Room and beating the Angel mini-boss.Mega Satan - Beat The Chest or The Dark Room once to unlock Key Piece 1 and Key Piece 2.To access The Dark Room, you need to beat Satan and touch the chest while The Negative is equipped.This item will always drop after the Mom fight once unlocked.

Dark Room: Killing Satan in Sheol 6 times will cause The Negative passive item to be unlocked.To access The Chest, you need to beat Isaac and touch the chest while The Polaroid is equipped.The Chest: Killing Isaac in The Cathedral 6 times will cause The Polaroid passive item to be unlocked.Sheol can also be reached by using the 'We Need To Go Deeper' item in The Womb II/Utero II/Scarred Womb II. Note that these levels can be reached earlier than this if a devil or angel room appear when you kill Mom's Heart (they will only contain the stairway or beam of light).The beam of light leads to the Cathedral.Beating It Lives will make a beam of light and stairway appear.Cathedral/ Sheol: Kill Mom's Heart 10 times, at which point Mom's Heart will be permanently replaced by It Lives.Boss Rush: Kill Mom in 20 minutes or less and enter the large crack that appears in the wall.

The binding of isaac antibirth mines knife piece